Clinical review: Prothrombin complex concentrates - evaluation of safety and thrombogenicity
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چکیده
منابع مشابه
Clinical review: Prothrombin complex concentrates - evaluation of safety and thrombogenicity
Prothrombin complex concentrates (PCCs) are used mainly for emergency reversal of vitamin K antagonist therapy. Historically, the major drawback with PCCs has been the risk of thrombotic complications. The aims of the present review are to examine thrombotic complications reported with PCCs, and to compare the safety of PCCs with human fresh frozen plasma. The risk of thrombotic complications m...
متن کاملCorrection: Clinical review: Prothrombin complex concentrates - evaluation of safety and thrombogenicity
Author details 1Haemostasis Research Unit, Centre for Haemostasis and Thrombosis, Department of Haematology and Oncology, Guy’s and St Thomas’ Hospital & NHS Trust Foundation, King’s College London School of Medicine, 1st Floor, North Wing, St Thomas’ Hospital, Westminster Bridge Road, London SE1 7EH, UK. 2Institute of Anesthesiology, University Hospital Zurich, CH-8091 Zurich, Switzerland. 3De...
متن کاملProthrombin complex concentrates: a brief review.
Prothrombin complex concentrates are haemostatic blood products containing four vitamin K-dependent clotting factors (II, VII, IX and X). They are a useful, reliable and fast alternative to fresh frozen plasma for the reversal of the effects of oral anticoagulant treatments (vitamin K antagonists). They are sometimes used for factor II or factor X replacement in patients with congenital or acqu...
متن کاملThrombogenic properties of prothrombin complex concentrates.
In a recent paper White et al.’ reported that the thrombogenic properties of prothrombin complex concentrates (PCC) are due to the presence of factors IXa and Xa. The presence of these activated factors, however, was detected indirectly by applying different inhibitors, e.g., a specific seryl reagent, phenylmethylsulfonyl fluoride (PMSF). They concluded that the effect of PMSF is due to the ina...
متن کاملPerioperative use of prothrombin complex concentrates.
Prothrombin complex concentrates (PCCs) are purified drug products with hemostatic activity derived from a plasma pool. Today, PCCs contain a given and proportional amount of four non-activated vitamin K-dependent coagulation factors (II, VII, IX, and X), a variable amount of anticoagulant proteins (proteins C and S, and in some antithrombin) and low-dose heparin. In some countries PCC products...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2011
ISSN: 1364-8535
DOI: 10.1186/cc9311